Mitochondrial Complex I Subunit Mf1 as A Potential Drug Target and Biomarker

Target Name: Mitochondrial complex I assembly complex

NCBI ID: P27122

Mitochondrial complex I assembly complex

Other Name(s): MCIA

Mitochondrial Complex I Subunit Mf1 as A Potential Drug Target and Biomarker

Mitochondrial Complex I (MCIA) is a protein complex that plays a crucial role in the function of mitochondria, which are organelles responsible for generating energy in the cell. MCIA is composed of multiple subunits that work together to maintain the stability and integrity of mitochondrial dynamics . One of the subunits, called mitofusin-1 (Mf1), has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and metabolic disorders.

The MCIA protein complex is composed of several subunits, including Mf1, Mf2, Mf3, Mf4, Mf5, and Mf6. These subunits form a structure that is similar to a mashed grass blade shape, with Mf1 at the center and Mf2, Mf3 , and Mf4 located at the corners. Mf5 and Mf6 are involved in the assembly and disassembly of the complex.

Mitofusin-1 (Mf1) is a key subunit of the MCIA protein complex that plays a central role in maintaining the stability and integrity of mitochondrial dynamics. Mf1 functions as a molecular chaperone, which means it helps to transport and guide other subunits to their proper locations and keeps them in a stable state. Mf1 also interacts with the protein p276 (also known as calbindin), which is involved in the regulation of mitochondrial dynamics and is a potential drug target for various diseases.

One of the functions of Mf1 is to regulate the assembly and disassembly of other subunits of the MCIA protein complex. For example, Mf1 has been shown to interact with Mf2 and Mf3, which are involved in the assembly of the complex, and Mf4, which is involved in the disassembly of the complex. Mf1 also interacts with Mf5 and Mf6, which are involved in the regulation of the stability and integrity of the complex.

In addition to its role in regulating the assembly and disassembly of the MCIA protein complex, Mf1 has also been shown to play a role in the regulation of mitochondrial dynamics and the expression of certain genes. For example, Mf1 has been shown to interact with the protein thioredoxin, which is involved in the regulation of mitochondrial dynamics and the expression of certain genes. Mf1 has also been shown to interact with the protein parkin, which is involved in the regulation of mitochondrial dynamics and the expression of certain genes.

Mitofusin-1 (Mf1) has also been shown to play a role in the regulation of cellular processes that are important for the survival and proliferation of cells. For example, Mf1 has been shown to interact with the protein p53, which is involved in the regulation of cellular processes that are important for the survival and proliferation of cells. Mf1 has also been shown to interact with the protein p21, which is involved in the regulation of cellular processes that are important for the survival and proliferation of cells.

Mitofusin-1 (Mf1) has also been shown to play a role in the regulation of cellular processes that are important for the development and progression of diseases. For example, Mf1 has been shown to interact with the protein p16INK4a, which is involved in the regulation of cellular processes that are important for the development and progression of diseases. Mf1 has also been shown to interact with the protein p53, which is involved in the regulation of cellular processes that are important for the development and progression of diseases.

In conclusion, Mitochondrial Complex I (MCIA) is a protein complex that plays a crucial role in the function of mitochondria. One of the subunits, Mf1, has

Protein Name: Mitochondrial Complex I Assembly Complex

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